Selected Papers Published
by Laboratory of Cell Growth 1993-2008

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  1. Chang TT and Hughes-Fulford M, Hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes. 2008 Aug; Tissue Engineering, Part A 15:3. Full Text
  2. Sevigny MB, Li C-F, Alas M and Hughes-Fulford M, Glycosylation regulates turnover of cyclooxygenase-2. 2006 Oct; FEBS Letters 580 6533-6536. Full Text
  3. Millie Hughes-Fulford,  Karsten Rodenaker, and Uta Jütting, Reduction of anabolic signals and alteration of osteoblast nuclear morphology in microgravity. Cellular Biochemistsry 99:435-449 (2006). Full Text
  4. C-F Li and M. Hughes-Fulford, FGF-2 is an immediate-early gene induced by mechanical stress in osteogenic cells. J Bone Miner Res. 2006 Jun;21(6):946-55. Full Text
  5. M. Hughes-Fulford, C-F Li, S. Sayyah, and J. Boonyaratanakornkit, Omega-6 fatty acids activate PI3K signaling and induce gene expression in prostate cancer Cancer Research 2006, 66 (3) 1427-1433 Full Text
  6. Boonyaratanakornkit JB, Cogoli A, Li CF, Schopper T, Pippia P, Galleri G, Meloni MA, Hughes-Fulford M. Key gravity-sensitive signaling pathways drive T cell activation. FASEB J. 2005 Dec;19(14):2020-2. Full Text
  7.   Hughes-Fulford M, Sugano E,  Schopper T, Li C-F, Boonyaratanakornkit J, Cogoli A. Early immune response and regulation of IL-2 receptor subunits, Cellular Signaling Sep;17 (9):1111-24, 2005 Full Text
  8. Hughes-Fulford M, Tjandrawinata RR, Li C-F, and Sayyah S. Arachidonic Acid, an Omega-6 Fatty Acid,  Induces Cytoplasmic Phospholipase A2 in Prostate Carcinoma Cells, Carcinogenesis, Sep;26(9):1520-6, 2005. Full Text
  9. Hughes-Fulford M. Signal transduction and mechanical stress. scienceonline Sci STKE. 2004 Aug 31;2004 (249):RE12. Full Text
  10. Hatton JP, Pooran M, Li CF, Luzzio C, Hughes-Fulford M. (2003). A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway. J Bone Miner Res. 18(1):58-66. Full Text
  11. Hughes-Fulford M. (2003). Function of the cytoskeleton in gravisensing during spaceflight. Adv Space Res. 32(8): 1585-93 Full Text
  12. Hatton JP, Gaubert F, Cazenave JP, Schmitt D.(2002). Microgravity modifies protein kinase C isoform translocation in the human monocytic cell line U937 and human peripheral blood T-cells. J Cell Biochem. 87(1):39-50. Full Text
  13. Hughes-Fulford M. The role of signaling pathways in osteoblast gravity perception. J Gravit Physiol. 2002 Jul;9(1):P257-60. Full text
  14. Hughes-Fulford M. (2002) Physiological effects of microgravity on osteoblast morphology and  cell biology. Adv Space Biol Med. 8:129-57. Full Text
  15. Millie Hughes-Fulford, (2002) Changes in gene expression in signal transduction in microgravity, Journal of Gravitational Physiology, P1-4 Full Text 
  16. Hughes-Fulford M, Chen Y, Tjandrawinata RR. (2001) Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells. Carcinogenesis. 22(5):701-7. Full Text
  17. Chen Y, Hughes-Fulford M. Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2. J Cancer. 1;91(1):41-5.2001Full Text
  18. Chen Y, Hughes-Fulford M.  Prostaglandin E2 and the protein kinase A pathway mediate arachidonic acid induction of c-fos in human prostate cancer cells. Br J Cancer 2000 Jun;82(12):2000-6 Full Text
  19. Lewis ML and Hughes-Fulford M,  Regulation of heat shock protein message in Jurkat cells cultured under serum-starved and gravity-altered conditions. J Cell Biochem. 2000 Apr;77(1):127-134. Full Text
  20. Fitzgerald J, Dietz TJ and Hughes-Fulford, M Prostaglandin E2-induced up-regulation of c-fos messenger ribonucleic acid is primarily mediated by 3',5'-cyclic adenosine monophosphate in MC3T3-E1 osteoblasts. Endocrinology. 2000 Jan;141(1):291-8. Full Text
  21. Hughes-Fulford, M., Using cell biology in planning the Mars Mission, The Biochemist 25-9, 1999  Full Text
  22. Lum,D., McQuaid,K and Hughes-Fulford, M. (1999) Co-ordinate up regulation of low density lipoprotein receptor and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas Int. J of Cancer. 8:83(2): 162-166 Full Text
  23. Fitzgerald, J and Hughes-Fulford, M (1999) Mechanically induced c-fos expression is mediated by cAMP in MC3T3-E1 osteoblasts FASEB J, 13: 553-557 Full Text
  24. Hughes-Fulford, Millie and Vicki Gilbertson. (1999) Osteoblast fibronectin mRNA, protein synthesis and matrix is not changed after long term exposure to microgravity. (1999) FASEB J 13, S121-128 Full Text
  25. Hughes-Fulford, Millie, Raymond Tjandrawinata, Jamie Fitzgerald, Kimberly Gasuad and Vicki Gilbertson. (1999) Effect of microgravity on osteoblast growth activation: Analysis of transcription, translation and morphology on STS-76. Biorack on Spacehab, by Brinkmann and Brillouet. ed: M. Perry European Space Agency ISBN 92-9092-484-5
  26. Hughes-Fulford, Millie and Vicki Vincent. (1998) Effects of microgravity on osteoblast growth. ASGSB Bulletin vol. 11(2), 51-60
  27. Hughes-Fulford M, (1997) Prostaglandin regulation of gene expression and growth in normal and malignant tissues Adv. Exp Med. Biol. 400A: 269-278
  28. Tjandrawinata, R.R.; Vincent, V.L. and Hughes-Fulford, M. (1997) Vibrational Force Alters mRNA 
  29. Hughes-Fulford M, (1997) Growth Regulation of Gardeners Syndrome Colorectal Cancer Cells by NSAIDs Adv. Exp Med. Biol. 407: 433-441
  30. Tjandrawinata, R and Hughes-Fulford, M (1997) Upregulation of Cyclooxygenase 2 by Product, Prostaglandin E2 in prostate cancer Adv. Exp Med. Biol. 407: 163-170
  31. Tjandrawinata,R., Rajvir, D and Hughes-Fulford, M. (1997) Induction of cyclooxygenase-2 mRNA by prostaglandin E2 in prostate cancer, British Journal of Cancer, 75:8: 1111-1118
  32. Hughes-Fulford, M. and Lewis, M. (1996) Effects of Microgravity on Osteoblast Growth Activation, Experimental Cell Research 224, 103-109 Full Text
  33. Leong,J, Hughes-Fulford M. Rakhlin, Habib A Maclouf, J and Goldyne, M. (1996) Cyclooxygenases in Human and Mouse Skin and Cultured Human Keratinocytes: association of COX-2 expression with Human Keratinocyte Differentiation Exp Cell Research 224, 79-87, Full Text
  34. Fitzgerald, J. and Hughes-Fulford, M. (1996) Gravitational Loading of a Simulated launch alters mRNA expression in osteoblasts, Experimental Cell Research 228,168-171 Full Text
  35. Lewis, ML and Hughes-Fulford, M. (1996) Cellular Responses to Microgravity, Chapter 3, Textbook for the International Space Univ. ed. S. Churchill. Harvard University, p 71-105
  36. Hughes-Fulford M. (1997) Growth regulation and gene expression in cancer and normal cells by prostaglandins. Adv Exp Med Biol, 400A, 269-278
  37. Hughes-Fulford M. (1994) G1 cell cycle arrest by dmPGA1: Up-regulation of c-fos and c-myc oncogene expression without transition into S-Phase in S49 lymphomas. J Cell Biochem, 54:265-272
  38. Lin HS, Hughes-Fulford M, (1993) Kumegawa M, and Snowdowne K. Cytoplasmic pH Influences Cytoplasmic Calcium in MC3T3-E1 osteoblast cells. J Bone and Miner Res. 8:725-732
  39. Hughes-Fulford M. (1993) Growth and repair of mineralized osteoblasts, Spinal Instability, Holtzman R, McCormick P, et. al. eds. Springer-Verlag, New York, 3-14
  40. Hughes-Fulford M, and Fukushima M. (1993) Control of cell cycle by metabolites of prostaglandin D2 through a non-cAMP mediated mechanism in lymphomas, Life Science Advances-Experimental and Clinical Endocrinology 12:57-64
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