LCG Home

 

T-Cell Research

Bone Research

Cancer Research

 

The team

 

Publications

 

Education

 

Previous Spaceflight Research

 

  

Selected Papers Published by Laboratory of Cell Growth 1993-2006

  1. Millie Hughes-Fulford,  Karsten Rodenaker, and Uta Jütting, Reduction of anabolic signals and alteration of osteoblast nuclear morphology in microgravity,  In Press. Cellular Biochemistsry

  2. Chai-Fei LI and M. Hughes-Fulford, FGF-2 is an immediate early gene mechanical stress, In Press, JBMR

  3. M. Hughes-Fulford, C-F Li, S. Sayyah, and J. Boonyaratanakornkit, Omega-6 fatty acids activate PI3K signaling and induce gene expression in prostate cancer Cancer Research 2006, 66 (3) 1427-1433 Full Text

  4. Boonyaratanakornkit JB, Cogoli A, Li CF, Schopper T, Pippia P, Galleri G, Meloni MA, Hughes-Fulford M. Key gravity-sensitive signaling pathways drive T cell activation. FASEB J. 2005 Dec;19(14):2020-2. Full Text

  5.   Hughes-Fulford M, Sugano E,  Schopper T, Li C-F, Boonyaratanakornkit J, Cogoli A. Early immune response and regulation of IL-2 receptor subunits, Cellular Signaling Sep;17 (9):1111-24, 2005 Full Text

  6. Hughes-Fulford M, Tjandrawinata RR, Li C-F, and Sayyah S. Arachidonic Acid, an Omega-6 Fatty Acid,  Induces Cytoplasmic Phospholipase A2 in Prostate Carcinoma Cells, Carcinogenesis, Sep;26(9):1520-6, 2005. Full Text

  7. Hughes-Fulford M. Signal transduction and mechanical stress. scienceonline Sci STKE. 2004 Aug 31;2004 (249):RE12. Full Text

  8. Hatton JP, Pooran M, Li CF, Luzzio C, Hughes-Fulford M. (2003). A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway. J Bone Miner Res. 18(1):58-66. Full Text

  9. Hughes-Fulford M. (2003). Function of the cytoskeleton in gravisensing during spaceflight. Adv Space Res. 32(8): 1585-93 Full Text

  10. Hatton JP, Gaubert F, Cazenave JP, Schmitt D.(2002). Microgravity modifies protein kinase C isoform translocation in the human monocytic cell line U937 and human peripheral blood T-cells. J Cell Biochem. 87(1):39-50. Full Text

  11. Hughes-Fulford M. The role of signaling pathways in osteoblast gravity perception. J Gravit Physiol. 2002 Jul;9(1):P257-60. Full text

  12. Hughes-Fulford M. (2002) Physiological effects of microgravity on osteoblast morphology and  cell biology. Adv Space Biol Med. 8:129-57. Full Text

  13. Millie Hughes-Fulford, (2002) Changes in gene expression in signal transduction in microgravity, Journal of Gravitational Physiology, P1-4 Full Text 

  14. Hughes-Fulford M, Chen Y, Tjandrawinata RR. (2001) Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells. Carcinogenesis. 22(5):701-7. Full Text

  15. Chen Y, Hughes-Fulford M. Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2. J Cancer. 1;91(1):41-5.2001Full Text

  16. Chen Y, Hughes-Fulford M.  Prostaglandin E2 and the protein kinase A pathway mediate arachidonic acid induction of c-fos in human prostate cancer cells. Br J Cancer 2000 Jun;82(12):2000-6 Full Text

  17. Lewis ML and Hughes-Fulford M,  Regulation of heat shock protein message in Jurkat cells cultured under serum-starved and gravity-altered conditions. J Cell Biochem. 2000 Apr;77(1):127-134. Full Text

  18. Fitzgerald J, Dietz TJ and Hughes-Fulford, M Prostaglandin E2-induced up-regulation of c-fos messenger ribonucleic acid is primarily mediated by 3',5'-cyclic adenosine monophosphate in MC3T3-E1 osteoblasts. Endocrinology. 2000 Jan;141(1):291-8. Full Text

  19. Hughes-Fulford, M., Using cell biology in planning the Mars Mission, The Biochemist 25-9, 1999  Full Text

  20. Lum,D., McQuaid,K and Hughes-Fulford, M. (1999) Co-ordinate up regulation of low density lipoprotein receptor and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas Int. J of Cancer. 8:83(2): 162-166 Full Text

  21. Fitzgerald, J and Hughes-Fulford, M (1999) Mechanically induced c-fos expression is mediated by cAMP in MC3T3-E1 osteoblasts FASEB J, 13: 553-557 Full Text

  22. Hughes-Fulford, Millie and Vicki Gilbertson. (1999) Osteoblast fibronectin mRNA, protein synthesis and matrix is not changed after long term exposure to microgravity. (1999) FASEB J 13, S121-128 Full Text

  23. Hughes-Fulford, Millie, Raymond Tjandrawinata, Jamie Fitzgerald, Kimberly Gasuad and Vicki Gilbertson. (1999) Effect of microgravity on osteoblast growth activation: Analysis of transcription, translation and morphology on STS-76. Biorack on Spacehab, by Brinkmann and Brillouet. ed: M. Perry European Space Agency ISBN 92-9092-484-5

  24. Hughes-Fulford, Millie and Vicki Vincent. (1998) Effects of microgravity on osteoblast growth. ASGSB Bulletin vol. 11(2), 51-60

  25. Hughes-Fulford M, (1997) Prostaglandin regulation of gene expression and growth in normal and malignant tissues Adv. Exp Med. Biol. 400A: 269-278

  26. Tjandrawinata, R.R.; Vincent, V.L. and Hughes-Fulford, M. (1997) Vibrational Force Alters mRNA 

  27. Hughes-Fulford M, (1997) Growth Regulation of Gardeners Syndrome Colorectal Cancer Cells by NSAIDs Adv. Exp Med. Biol. 407: 433-441

  28. Tjandrawinata, R and Hughes-Fulford, M (1997) Upregulation of Cyclooxygenase 2 by Product, Prostaglandin E2 in prostate cancer Adv. Exp Med. Biol. 407: 163-170

  29. Tjandrawinata,R., Rajvir, D and Hughes-Fulford, M. (1997) Induction of cyclooxygenase-2 mRNA by prostaglandin E2 in prostate cancer, British Journal of Cancer, 75:8: 1111-1118

  30. Hughes-Fulford, M. and Lewis, M. (1996) Effects of Microgravity on Osteoblast Growth Activation, Experimental Cell Research 224, 103-109 Full Text

  31. Leong,J, Hughes-Fulford M. Rakhlin, Habib A Maclouf, J and Goldyne, M. (1996) Cyclooxygenases in Human and Mouse Skin and Cultured Human Keratinocytes: association of COX-2 expression with Human Keratinocyte Differentiation Exp Cell Research 224, 79-87, Full Text

  32. Fitzgerald, J. and Hughes-Fulford, M. (1996) Gravitational Loading of a Simulated launch alters mRNA expression in osteoblasts, Experimental Cell Research 228,168-171 Full Text

  33. Lewis, ML and Hughes-Fulford, M. (1996) Cellular Responses to Microgravity, Chapter 3, Textbook for the International Space Univ. ed. S. Churchill. Harvard University, p 71-105

  34. Hughes-Fulford M. (1997) Growth regulation and gene expression in cancer and normal cells by prostaglandins. Adv Exp Med Biol, 400A, 269-278

  35. Hughes-Fulford M. (1994) G1 cell cycle arrest by dmPGA1: Up-regulation of c-fos and c-myc oncogene expression without transition into S-Phase in S49 lymphomas. J Cell Biochem, 54:265-272

  36. Lin HS, Hughes-Fulford M, (1993) Kumegawa M, and Snowdowne K. Cytoplasmic pH Influences Cytoplasmic Calcium in MC3T3-E1 osteoblast cells. J Bone and Miner Res. 8:725-732

  37. Hughes-Fulford M. (1993) Growth and repair of mineralized osteoblasts, Spinal Instability, Holtzman R, McCormick P, et. al. eds. Springer-Verlag, New York, 3-14

  38. Hughes-Fulford M, and Fukushima M. (1993) Control of cell cycle by metabolites of prostaglandin D2 through a non-cAMP mediated mechanism in lymphomas, Life Science Advances-Experimental and Clinical Endocrinology 12:57-64


home